Product licences for alemtuzumab and multiple sclerosis.
نویسندگان
چکیده
www.thelancet.com Vol 383 March 8, 2014 867 sexual violence that we did not ask about, which is a matter of regret. When designing the questionnaire, about 5 years ago, sexual violence had not fully come to the fore as a topic of public health importance and new questions were required to compete with a wide range of topics traditionally included in the survey. This is certainly a section of the survey that we will seek to develop for Natsal-4. We do not ask questions about sexual experiences at age 12 years or younger, whether consensual or otherwise, on the grounds that this is likely to be an overly sensitive area for (generalist) interviewers to deal with. Querying on the part of ethical review committees, even of questions probing sexual experience before 16 years of age, suggests that we would have had diffi culty in obtaining ethical approval had we sought to do so.
منابع مشابه
Listeria monocytogenes infection associated with alemtuzumab – - a case for better preventive strategies
BACKGROUND The mortality of septicaemia, meningitis and encephalitis caused by Listeria monocytogenes is 20-40%. Twenty-one cases of invasive listeriosis associated with alemtuzumab, including at least 16 in patients with multiple sclerosis, have been published or reported to the World Health Organization Case Safety Reports Database. Three cases were fatal, including at least one patient treat...
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متن کاملMagnetization transfer imaging in multiple sclerosis treated with alemtuzumab.
The magnetization transfer ratio reflects the integrity of tissue structure, including myelination and axonal density. Mean magnetization transfer ratio fell in 18 untreated patients with multiple sclerosis both in normal appearing grey (-0.25 pu/year, p < 0.001) and white matter (-0.12 pu/year, p = 0.004). Conversely, mean magnetization transfer ratio was stable in 20 alemtuzumab-treated patie...
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ورودعنوان ژورنال:
- Lancet
دوره 383 9920 شماره
صفحات -
تاریخ انتشار 2014